Comes to Port Charles to seek revenge for his brother's death, and remains always at war with Sonny Corinthos. Responsible for the death of Kristina Cassadine with a bomb meant for Sonny Corinthos at his coffee warehouse. In the process, he fell in love with Wu's granddaughter, Jade. Came to Port Charles to learn more about Ryan's mental illness. Character moved to the General Hospital spin-off, Port Charles, in 1997. Returned to Port Charles in 2013 when Lucy was committed to Ferncliff. Dated Miguel Morez and had a son with him (Juan Santiago). Informed Sonny that Brenda, working for the FBI, had been recording them together. Floyd announced in December 2011 that he would be going by his middle name, Prescott. Killed by Lulu Spencer in self-defense after an ill-fated romance. Father of the deceased Aleksander Janacek, whom Brenda accidentally killed. Pretended to help Luke and Laura search for the Left-Handed Boy but was instead after Frank Smith's gold., Sonny Corinthos, Lorenzo Alcazar and Jasper Jacks. Mother to Michael Corinthos III, Morgan Corinthos and Josslyn Jacks. Ex-husband of Miranda Jameson, Alexis Davis, Courtney Matthews, Skye Chandler Quartermaine and Carly Corinthos Jacks.

Briefly marries Carly Corinthos and has an affair with Skye Quartermaine that produces Lila Rae. Killed in self-defense by Kristina's newfound sister Alexis Davis after being pushed off his balcony in 2002. Former madam; longtime manager of Kelly's Diner and at one time, a cleaning woman at both General Hospital and the Webber residence. Judge who presided over the trial against Sonny Corinthos for the death of Claudia Zacchara. Appeared as a dream in 2010, when Robin was trapped in a well. Former rock singer turned mental patient, after his wife, Livvie Locke, died. Went on a killing spree, believing he was an actual vampire named Caleb Morley. Mob boss of Port Charles, New York, owner of clubs in the Caribbean, and legitimate coffee importer. A French mastiff adopted by Luke, Laura and Lucky Spencer. His secret alias was "The Balkan", and he worked as an international criminal dealing in drugs and the exploitation of women and children. Killed by Suzanne before he had the chance to meet his grandson, Alec. Had an affair with Sean Donely and became pregnant with his child. As of 2012, according to Edward, Jimmy Lee and Charity do not have any children. Ex-wife of Johnny Zacchara as her split personality Connie Falconeri. Originally came to town to break up her mother Bobbie Spencer's marriage.

Works as Nikolas Cassadine's private escort until 2011, when she again leaves town to pursue a singing career. One of the seven assailants that take the Metro Court Hotel hostage. Lover and housemate of Jimmy Lee and nemesis of Celia Quartermaine. Abandoned Sam and left her with Cody when Sam was very young. Was the victim of a hit-and-run accident caused by Alexis Davis, dying from his internal injuries shortly after arriving to General Hospital. Shot Mac Scorpio and Ethan Lovett to avenge his son's demise. Had a heart attack and died after cursing Sam Morgan. Ex-lover of Courtney Matthews, Rebecca Shaw, Elizabeth Webber and Britt Westbourne. Son of Mikkos Cassadine and Helena Cassadine of the Cassadine family. Put in charge of the Quartermaine family business to keep it from being used as a front for illegal activity. Ex-wife of Asa Buchanan, Todd Manning, Max Holden, Victor Lord Jr., John Mc Bain, and Elijah Clarke. Fathered Raoul after running away with Annabelle, the Quartermaine’s French Briard, making him the enemy of Edward Quartermaine. Only referred to off-screen after Lucky left the Spencer home. Artist and serial killer who terrorized Jason Morgan and many people who Jason cared about. Son of Maximus Giambetti and brother of Milo Giambetti.

Married Laura Webber when she was 18, but she subsequently went to work for Luke Spencer at his disco, where he raped her, but she fell in love with him and divorced Scott to marry Luke. Younger paternal half-sister of Elizabeth, Sarah, and Steven Lars Webber. Grandson of Harlan Barrett, Veronica Wilding, Theo Hoffman, and Suzanne Stanwyck. Hidden away from Brenda, by his grandmother Suzanne Stanwyck. Maternal half-sister of Sam Morgan and Molly Lansing. She and Robert Scorpio spar when they first meet, but the duo quickly becomes attracted to one another. Commits adultery with Jessica Holmes, and she becomes pregnant. Dated Leyla Mir, Lisa Niles, Britt Westbourne, Sabrina Santiago, and Sam Morgan.

Father of Robert "Franco" Frank, Karen Wexler, Logan Hayes, Serena Baldwin, and Christina Baldwin. Daughter of Scott Baldwin and Dominique Stanton Baldwin. Was married to Nikolas Cassadine at the time of his death. Paternal half-sister of Dante Falconeri, Morgan Corinthos, Lila Mc Call and Avery Corinthos; adoptive paternal half-sister of Michael Corinthos III. Robert and Katherine become engaged, but Duke Lavery's death interrupts and indefinitely postpones their marriage. Killed by his daughter Julie Morris-Devlin, while under the control of Greg Cooper. It is not known whether Sean is the father of the child, as Jessica is murdered by Ryan Chamberlain before the baby is born.

The Jewish financier for Corinthos and Morgan and Benny's identical twin brother. Shot in 2011, and blackmailed by Cesar Faison, posing as Duke Lavery.

Dies during a shootout, after being shot by Joe Scully, Jr. Son of Maria Sanchez and Lorenzo Alcazar, raised thinking Maria is his sister to hide him from his father.

Daughter of Lorenzo Alcazar and Skye Chandler Quartermaine. Adoptive parental half-sister of Michael Corinthos III. First wife of Sonny Corinthos and was married to him at the time of her death. Paternal half-brother of Kristina Davis, Morgan Corinthos, Lila Mc Call, and Avery Corinthos, and maternal half-brother of Leo Falconeri. Adoptive paternal half-brother of Michael Corinthos III. Romanced Sonny Corinthos back in Bensonhurst when the two were teenagers. Mother of Dante Falconeri with Sonny and Leo Falconeri with Julian Jerome. Later that day, in an ironic twist, Edward suffered a heart attack because of the poisoning, causing him to lose control of his car and run down Andrea. Mayor of Port Charles from 2006 until 2012, when he was replaced by Janice Lomax. Initially a suspect in the murder of his mistress Brianna Hughes, for which his wife Andrea was later found guilty. Formerly worked as a stripper under the name Candy and attended college part-time to become a paralegal. Died after being struck in the head by construction debris in Chicago. Illegitimate son of Scott Baldwin and Jacqueline Hayes. Henchman of Frank Smith who, originally ordered to get rid of Luke and Laura, became friends with them.

Adoptive member of the Quartermaine family, named after her adoptive great-grandmother Lila Quartermaine, and her grandmother Rae Cummings. Brother of Luis Alcazar and father of Diego Alcazar and Lila Rae Alcazar. Committed several murders; fixated on Felicia Jones because of her resemblance to his mother, who sexually abused him while growing up. Yank's younger brother Tei was killed early on in the Asian Quarter mystery, spurring him to help Robert Scorpio and his pals break up Wu's gang. While pregnant with Sonny's child, she was killed by her mob boss father Hernando Rivera (deceased) in a car bombing meant for Sonny. Originally came to town as an undercover police officer, wanting to take down Sonny, not knowing he was his father. Part of the Spencer family and part of the Corinthos family by marriage. Maternal half-sister of Nikolas Cassadine and paternal half-sister of Ethan Lovett. Was impregnated by Dillon Quartermaine in 2006 and had an abortion. In an attempt to protect himself, he brought to light his brief 2006 affair with District Attorney Alexis Davis. Brother of Robert "Franco" Frank, Karen Wexler, Serena Baldwin, and Christina Baldwin. Worked with Luke and Laura at Mom and Pop Calhoun's Diner and lived with them on the Whitakers' farm. Also known as James Craig and James Brosnan, he is responsible for the Metro Court Hotel hostage crisis in February 2007.

Roommate to Heather Webber in the Forest Hill Sanitarium. In 1983, Evan raped Camellia Mc Kay and she killed him in self defense; Duke Lavery covers up his murder.

Keeps all of Heather's secrets when Heather is escaping the sanitarium to kill Diana Taylor.

Marries Arielle Gastineau (whom he later divorced) and was utilized by Tracy in many of her schemes. Left Port Charles after Tracy turned down his marriage proposal. Robs Kelly's Diner and shoots Jagger Cates when Jagger protects Ruby Anderson. Supposedly falls to his death after fighting with Jason Quartermaine and Jagger Cates, but resurfaces and is sent to prison. Held Bobbie Spencer hostage while trying to make a run for it, later poisoning her with the toxin. Swedish opera singer who uses the stage name Kristin Nilsson. Killed Sage Alcazar and Trent Parker in the Quartermaine mansion. Mysterious mercenary who arrived in Port Charles in early 2011. Uncle of Nikolas Cassadine, and raised him like a son. Ex-wife of Ric Lansing, Jasper Jacks, and Julian Jerome. Defense attorney for Sonny Corinthos and law firm partner of Diane Miller. Maximus then flees the country in order to avoid the FBI.

Came back briefly as part of another ELQ take-over attempt. Son of David Bordisso and Meg Bentley, adopted by Lee Baldwin. Killed by Lorenzo Alcazar after he allegedly switched her medication. Daughter of Sonny Corinthos and Alexis Davis; part of the Cassadine family and Corinthos family. Katherine's family mysteriously dies in accidents secretly arranged by Katherine's cousin and fiancé.

Dated hospital administrator Dan Rooney but turned down his marriage proposal because she believed she wasn't good enough for him. Tried to kill his sister Olivia and later sent to prison along with his mother. Half-sister of former police detective Marcus Taggert. Became world famous model as "The Face of Deception". Ultimately sentenced Michael Corinthos III to five years in the Pentonville prison when his involvement was revealed. Was the chief villain in the Ice Princess affair, where he put North America into a deep freeze in mid-July. Sonny named his second son Morgan Stone after Jason Morgan and Stone. Brutally raped Carla Greco after she turned down his marriage proposal. Came to town looking for his "son," Rafe Kovich, Jr., and Sam Morgan, a lookalike of his wife. The leader of the Corinthos-Morgan Mob Organization/Imports. Husband of Carly Corinthos; ex-husband of Brenda Barrett; widower of Lily Rivera and Claudia Zacchara. As a stray, he was hit by a car, prompting Lucky Spencer to walk again after being shot. Attempted to marry Maxie Jones, the daughter of Felicia Cummings, in order to acquire the Aztec Jewels. Murdered by Ryan Chamberlain but both Sean Donely and TIffany Hill were suspected of committing the crime. Buzz Stryker, whose daughter Sandy had a huge crush on him. Revealed to have been disinherited by Edward in 2013. Had a childhood romance with Sonny Corinthos back in Bensonhurst. as a teenager; as a result, biological mother of Trey Mitchell. Co-owner of the Metro Court Hotel with Carly Jacks. Australian business tycoon, co-owner of the Metro Court Hotel until he sells his half to Kate Howard.